A Bad Experience
Two days ago, Margan and I had a disturbing experience. She saw an ad on Facebook for an RSV vaccine study. RSV is respiratory syncytial virus, and cases in the U.S. are exploding . Along with covid and flu, some are predicting a very bad respiratory season dubbed a “tripledemic” . As a pediatric infectious disease physician, Margan has lots of experience in dealing with severe RSV infection in infants and I am well aware it is also a threat at the other extreme of life. In the mid-1960s a formalin-inactivated RSV was developed but quickly dropped when it became apparent that it enhanced RSV disease rather than protecting from i t. Researchers have been trying to understand this problem and construct vaccines that truly are protective against RSV disease. Now multiple vaccines are in trials that seem to have overcome the problem of that 1960s-era vaccine. Bavarian Nordic has developed an RSV vaccine that uses its Modified Vaccinia Ankara to deliver 5 RSV antigens and create neutr